Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal aims to publish high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modeling. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.
- David Moher, Ottawa Hospital Research Institute
- Paul G Shekelle, RAND Corporation
- Lesley A Stewart, CRD, University of York
As the methodological aspects to a systematic review develop, the key principles behind them may need to be reevaluated to address more complex questions and interventions; for example, future research should focus on publication bias in qualitative research and the incorporation of a systems perspective.
Chiropractic care is often used for patients with low back pain. To estimate the clinical effectiveness and cost-effectiveness of chiropractic care in patients with non-specific low back pain, two systematic reviews will be conducted.
Health care decisions often need to be made in a timely fashion. Information on processes and methods from a range of international rapid review programs were collated to help understand the underlying themes associated with these programs.
When it comes to health system decisions there is no procedure for rapid syntheses of best available evidence; a stakeholder meeting discussed the current challenges and how to develop a rapid-response program for health system decision-makers in Canada.
Meta-analysis of test accuracy studies: an exploratory method for investigating the impact of missing thresholds
Meta-analysis of test accuracy studies with multiple thresholds can be affected if the primary studies have different or missing threshold data. An exploratory method to assess the impact of missing thresholds on conclusions from a test accuracy meta-analysis revealed results are vulnerable to the missing data.
Latest from PROSPERO
- A systematic review of cognitive function and psychosocial well-being in school-age children with narcolepsy
- A systematic review of the effects of stopping topical steroids in children: topical steroid withdrawal
- Accuracy of assessment instruments for patients' competence to consent to medical treatment or research. [Cochrane Protocol]
Systematic reviews reporting
Systematic Reviews advocates the complete and transparent reporting of research. Authors are required to adhere to the PRISMA Statement for any submitted systematic reviews, and required to follow the PRISMA-P Statement for protocol articles. The Editors also encourage authors to follow any relevant extensions to the PRISMA Statement, available from the EQUATOR Network.
Dr. David Moher is a senior scientist at the Clinical Epidemiology Program, Ottawa Hospital Research Institute, and Associate Professor, Department of Epidemiology and Community Medicine, University of Ottawa. Dr. Moher has been involved in systematic reviews for more than 20 years and has made contributions to the conduct and reporting of systematic reviews. Dr. Moher is associated with many journals, is a member of the advisory board for the International Congress on Peer Review and Biomedical Publication, and a member of the EQUATOR Network's steering group.
In addition to currently serving as a Staff Physician at the West Los Angeles Veterans Affairs Medical Center, Dr. Shekelle has served as the Director of the Southern California Evidence-based Practice Center for the RAND Corporation since 1997. He is also a Professor of Medicine at the University of California, Los Angeles (UCLA) School of Medicine. He is widely recognized in the field of guidelines, quality measurement, and evidence-based medicine. Dr. Shekelle has extensive experience in the health care arena and was previously the methodologist for the Agency for Health Care Policy and Research (now the Agency for Healthcare Research and Quality [AHRQ]) Low-Back Guidelines Panel, and he has participated in a number of other guideline development activities. He is currently the chair of the Clinical Guidelines Committee of the American College of Physicians.
Professor Lesley Stewart is Director of the Centre for Reviews and Dissemination (CRD) at the University of York and is a National Institute for Health Research (NIHR) Senior Investigator. Lesley has been involved in evidence synthesis in healthcare since the late 1980's, previously running the Medical Research Council Clinical Trials Unit meta-analysis research programme. Together with colleagues in Cambridge and Oxford, she helped establish the methodology and framework for individual patient data (IPD) reviews and was a founding member of the Cochrane Collaboration. Her research interests include the avoidance of bias and development of IPD methods and approaches to systematic review. Recently, she has instigated the development of PROSPERO an international register for the prospective registration of systematic reviews.