Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal aims to publish high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modeling. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.
- David Moher, Ottawa Hospital Research Institute
- Paul G Shekelle, RAND Corporation
- Lesley A Stewart, CRD, University of York
The AHRQ and EPC Program evaluated the literature on rapid reviews; results indicate that definition, methods and applications vary considerably. Those producing rapid reviews need to consider the transparency of their methods and development of reporting guidelines.
The Epstein-Barr virus latent membrane protein-1 (LMP1) 30-bp deletion and XhoI-polymorphism in nasopharyngeal carcinoma
Epstein-Barr virus is believed to be associated with nasopharyngeal carcinoma; meta-analyses suggest that for those with Epstein-Barr virus, there is an association between the LMP1 30-bp deletion and XhoI-loss with nasopharyngeal carcinoma susceptibility.
Brief interventions for alcohol misuse involve screening and providing feedback to patients, which aim to reduce their alcohol consumption. Brief intervention mechanisms were most influenced by the context, including aspects such as emotional state and severity of alcohol use or injury.
Insertion torque recordings for the diagnosis of contact between orthodontic mini-implants and dental roots
A common adverse event during orthodontic mini-implant insertion is contact with a dental root, causing potential permanent damage. Increased torque levels recorded at insertion could provide more clinical insight into the target condition than radiographic imaging, the standard reference.
Evaluation of organisational performance standards requires relevant minimum data sets to be collected to analyse key performance indicators; results indicate that collection of hospital data and data recording improvements may be cost-saving.
Latest from PROSPERO
- A rapid review and meta-analysis of interventions to reduce use of prescribed opioids in patients with chronic non-malignant pain
- A common reference-based indirect comparison meta-analysis of buccal versus intranasal midazolam for early convulsive status epilepticus
- A review of psychotherapies for older adults with cognitive impairment including dementia and their caregivers on facilitating acceptance, decision making and improving quality of life
- A systematic review and meta-analysis of the incidence of psychotic disorders in Brazil, France, Italy, the Netherlands and Spain
Systematic reviews reporting
Systematic Reviews advocates the complete and transparent reporting of research. Authors are required to adhere to the PRISMA Statement for any submitted systematic reviews, and required to follow the PRISMA-P Statement for protocol articles. The Editors also encourage authors to follow any relevant extensions to the PRISMA Statement, available from the EQUATOR Network.
Dr. David Moher is a senior scientist at the Clinical Epidemiology Program, Ottawa Hospital Research Institute, and Associate Professor, Department of Epidemiology and Community Medicine, University of Ottawa. Dr. Moher has been involved in systematic reviews for more than 20 years and has made contributions to the conduct and reporting of systematic reviews. Dr. Moher is associated with many journals, is a member of the advisory board for the International Congress on Peer Review and Biomedical Publication, and a member of the EQUATOR Network's steering group.
In addition to currently serving as a Staff Physician at the West Los Angeles Veterans Affairs Medical Center, Dr. Shekelle has served as the Director of the Southern California Evidence-based Practice Center for the RAND Corporation since 1997. He is also a Professor of Medicine at the University of California, Los Angeles (UCLA) School of Medicine. He is widely recognized in the field of guidelines, quality measurement, and evidence-based medicine. Dr. Shekelle has extensive experience in the health care arena and was previously the methodologist for the Agency for Health Care Policy and Research (now the Agency for Healthcare Research and Quality [AHRQ]) Low-Back Guidelines Panel, and he has participated in a number of other guideline development activities. He is currently the chair of the Clinical Guidelines Committee of the American College of Physicians.
Professor Lesley Stewart is Director of the Centre for Reviews and Dissemination (CRD) at the University of York and is a National Institute for Health Research (NIHR) Senior Investigator. Lesley has been involved in evidence synthesis in healthcare since the late 1980's, previously running the Medical Research Council Clinical Trials Unit meta-analysis research programme. Together with colleagues in Cambridge and Oxford, she helped establish the methodology and framework for individual patient data (IPD) reviews and was a founding member of the Cochrane Collaboration. Her research interests include the avoidance of bias and development of IPD methods and approaches to systematic review. Recently, she has instigated the development of PROSPERO an international register for the prospective registration of systematic reviews.