Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal aims to publish high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modeling. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.


  • David Moher, Ottawa Hospital Research Institute
  • Paul G Shekelle, RAND Corporation
  • Lesley A Stewart, CRD, University of York


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  • A Microsoft-Excel-based tool for running and critically appraising network meta-analyses (NetMetaXL)

    The most commonly used software package to conduct network meta-analyses is WinBUGS, though its use can be challenging. Here, the authors developed NetMetaXL, a Microsoft-Excel-based tool that is more accessible to novice users and allows network meta-analyses to be conducted entirely within Microsoft Excel.

    Systematic Reviews 2014, 3:110
  • Knowledge, attitudes and practices on adolescent vaccination among parents, teachers and adolescents in Africa

    Despite progress in the field of adolescent health, vaccine-preventable diseases and deaths still affect young people in Africa. Therefore, this systematic review aimed to assess the knowledge, attitudes and practices of adolescent vaccination in Africa to identify areas to improve vaccine uptake.

    Systematic Reviews 2014, 3:100
  • Adverse effects of small-volume red blood cell transfusions in the neonatal population

    Red blood cell transfusions in the neonatal population are linked to the development of morbidities unique to neonates, though generally adverse transfusion reactions in the neonatal population are poorly understood. This review will evaluate reported adverse effects attributed to small-volume red blood cell transfusions in the neonatal population.

    Systematic Reviews 2014, 3:92
  • Evidence-based mapping of design heterogeneity prior to meta-analysis

    Design heterogeneity assessments during meta-analyses are usually presented post-hoc to explain statistical heterogeneity. This study highlights the importance of reporting design heterogeneity prior to statistical summarisation, along with ways to improve its assessment, which ultimately provides more evidence for interpreting risk estimates.

    Systematic Reviews 2014, 3:80
  • Systematic-Review Automation Technologies

    The production of systematic reviews can often be delayed due to cost of production, availability of the requisite expertise and timeliness. Here, the authors evaluated the potential impact of advancements in informatics systems that support or automate different stages of the systematic review process.

    Systematic Reviews 2014, 3:74
Systematic Reviews - Cochrane series widget
Extend or Update Previously Published Systematic Reviews
BioMed Central Author Academy
International Clinical Trials

Rapid reviews call for papers

Systematic Reviews is encouraging the submission of methodological papers concerning the conduct and reporting of rapid reviews, along with rapid review results papers. Please see the call for papers information page for more details.

Editors' profiles

David Moher

David MoherDr. David Moher is a senior scientist at the Clinical Epidemiology Program, Ottawa Hospital Research Institute, and Associate Professor, Department of Epidemiology and Community Medicine, University of Ottawa. Dr. Moher has been involved in systematic reviews for more than 20 years and has made contributions to the conduct and reporting of systematic reviews. Dr. Moher is associated with many journals, is a member of the advisory board for the International Congress on Peer Review and Biomedical Publication, and a member of the EQUATOR Network's steering group.

Paul Shekelle

Paul ShekelleIn addition to currently serving as a Staff Physician at the West Los Angeles Veterans Affairs Medical Center, Dr. Shekelle has served as the Director of the Southern California Evidence-based Practice Center for the RAND Corporation since 1997. He is also a Professor of Medicine at the University of California, Los Angeles (UCLA) School of Medicine. He is widely recognized in the field of guidelines, quality measurement, and evidence-based medicine. Dr. Shekelle has extensive experience in the health care arena and was previously the methodologist for the Agency for Health Care Policy and Research (now the Agency for Healthcare Research and Quality [AHRQ]) Low-Back Guidelines Panel, and he has participated in a number of other guideline development activities. He is currently the chair of the Clinical Guidelines Committee of the American College of Physicians.

Lesley Stewart

Lesley Stewart Professor Lesley Stewart is Director of the Centre for Reviews and Dissemination (CRD) at the University of York and is a National Institute for Health Research (NIHR) Senior Investigator. Lesley has been involved in evidence synthesis in healthcare since the late 1980's, previously running the Medical Research Council Clinical Trials Unit meta-analysis research programme. Together with colleagues in Cambridge and Oxford, she helped establish the methodology and framework for individual patient data (IPD) reviews and was a founding member of the Cochrane Collaboration. Her research interests include the avoidance of bias and development of IPD methods and approaches to systematic review. Recently, she has instigated the development of PROSPERO an international register for the prospective registration of systematic reviews.
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ISSN: 2046-4053