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Open Access Protocol

Hysterosalpingosonography for diagnosing tubal occlusion in subfertile women: a systematic review protocol

Sarah Maheux-Lacroix12*, Amélie Boutin2, Lynne Moore2, Marie-Ève Bergeron12, Emmanuel Bujold12, Philippe Y Laberge12, Madeleine Lemyre12 and Sylvie Dodin12

Author Affiliations

1 Département d’Obstétrique, Gynécologie et Reproduction, Université Laval, 2325, Rue de l’Université, Québec, QC, G1V 0A6, Canada

2 Centre de Recherche du CHU de Québec, 2705, Boulevard Laurier, Québec, QC, G1V 4G2, Canada

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Systematic Reviews 2013, 2:50  doi:10.1186/2046-4053-2-50

Published: 4 July 2013

Abstract

Background

Hysterosalpingosonography has been suggested as a less invasive alternative to hysterosalpingography for detecting tubal occlusion among subfertile women. We aim to determine the diagnostic accuracy of hysterosalpingosonography and to compare it to hysterosalpingography.

Methods/design

We will conduct a systematic review of diagnostic test accuracy. We will search Medline, Embase, Cochrane Library, Web of Science and Biosis, as well as reference lists of included studies and previous related review articles. Diagnostic studies that compared hysterosalpingosonography ± hysterosalpingography to laparoscopy with chromotubation in women suffering from subfertility will be eligible. Two authors will independently screen for inclusion, data extraction, and quality assessment. Methodological quality will be assessed using the Quality Assessment of Diagnostic Accuracy Study 2 tool (QUADAS-2). We will use SAS 9.3 (SAS Institute Inc., Cary, NC, USA, 2011) to program bivariate random-effects models, estimate pooled sensitivity and specificity with 95% confidence intervals and to generate summary receiver operating characteristics curves. We will perform sensitivity analyses to examine the effect of differences in techniques used for hysterosalpingosonography and in methodological quality of studies.

Discussion

This systematic review will help to determine if hysterosalpingosonography is an adequate alternative screening test for diagnosing tubal occlusion. Accuracy of specific sono-HSG techniques may also be identified.

Systematic review registration

This review has been registered at PROSPERO. The registration number is CRD42013003829

Keywords:
Hysterosalpingosonography; HyCoSy; Hysterosalpingography; Tubal patency; Subfertility; Diagnostic test accuracy; Systematic review; Meta-analysis